Vitamin B12 testing is commonly requested in the investigation of anaemia, cognitive decline, and neurological symptoms — yet interpretation can be more complex than it first appears.
This course reviews the physiology of B12 transport and function, including the roles of intrinsic factor, transcobalamin (Active B12), and haptocorrin. It explores dietary deficiency, malabsorption causes such as pernicious anaemia and gastric surgery, and high-risk populations including elderly patients and those following vegetarian or vegan diets.
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Understand the physiological role of Vitamin B12 in DNA methylation and neurological function
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Interpret total B12 and Active B12 (HoloTC) results appropriately
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Identify high-risk populations for B12 deficiency
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Understand when to consider functional testing (homocysteine, MMA)
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Recognise neurological & haematological manifestations of deficiency
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Choose appropriate treatment strategies, including when intramuscular B12 is required
