Lymphocytosis

A practical approach to interpreting lymphocytosis and distinguishing benign from serious haematological conditions.

  • CPD: 1HR
  • Case Study
  • Instructor: Dr Georgia Mills
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Course contents

Lymphocytosis is a common laboratory finding, but its clinical significance can vary widely — from benign, reactive processes to serious haematological malignancies.

This course uses a real-world case to explore how an incidental finding of lymphocytosis can lead to the diagnosis of chronic lymphocytic leukaemia (CLL), a typically slow-growing condition that often requires monitoring rather than immediate treatment.

Designed for primary care, this course supports confident interpretation of abnormal blood results and appropriate clinical decision-making.

You will learn how to:
  • Differentiate reactive from clonal causes of lymphocytosis
  • Recognise features suggestive of acute versus chronic leukaemia
  • Understand the role of blood film morphology and flow cytometry
  • Identify monoclonal B lymphocytosis (MBL) and its clinical significance
  • Apply appropriate monitoring strategies for asymptomatic patients
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Lymphocytosis