This on-demand course explores the limitations of HbA1c testing through a real clinical case where results did not align with the patient’s glycaemic status. It highlights how haemoglobin variants can interfere with different HbA1c assay methods and outlines practical alternatives, including fructosamine. The course provides clear guidance on recognising unreliable results and working with the laboratory to support accurate diabetes management
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Overview of HbA1c and its role in diabetes monitoring
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Case study exploring discordant HbA1c results
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Impact of haemoglobin variants on HbA1c accuracy
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Comparison of HbA1c assay methods (HPLC vs enzymatic)
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Use of fructosamine as an alternative marker
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Use of fructosamine as an alternative marker
